Kulanjan or Fingerroot (Alpinia Galanga Linn.)

Battle With Covid-19

Kulanjan or Fingerroot

Remdesivir Comparable Docking Score

WHO reports that worldwide currently 235 million people are affected by asthma. Asthma is an immune-mediated disease in which T helper (Th) cells play an important role. Asthma upregulates cytokines that promote chronic inflammation of the respiratory system. The inflammatory response causes airway obstruction and can ultimately result in death.

The Kulanjan has been found having great healing properties for treating cough and Asthma, Suggested to consume with honey.

Its a member of the Ginger family but differs from Zingiber officinale, which is commonly used in Western cuisine.

In Asthmatic patients, the situation rapidly worsens for the increase in existing inflammation since both Asthma and the virus Sars-Cov-2 targets lung epithelial cells, and activates microphoning.

Kulanjan has been approved by the Thailand govt for emergency use for treating Covid-19 patients.

A team of Korean researchers ( Joung-Wook Seo et al.) found that the compound

1′-Acetoxychavicol Acetate (ACA; 50 mg/kg/day) isolated from Kulanjana controls asthma similar to those of dexamethasone-treated controls in a dose dependent manner. ACA suppressed T cells but had little or no effect on B cells.

In another computational docking study conducted by Indonesian researchers Bambang Cahyono et al., its found that the all three primary compounds of Kulanjana – Galangin, Kaempferitrin, and ACA have got higher binding affinity with virus SARS-Cov-2 proteins, the virus depends for its replication leading to spreading infection.

Kulanjana compounds exhibited desirable low docking score well within root-mean-square deviation (RMSD) value range 1.5 A to 2 Å which are comparable to that of Remdesivir and Chloroquine.

References: Seo JW, Cho SC, Park SJ, et al. 1′-Acetoxychavicol acetate isolated from Alpinia galanga ameliorates ovalbumin-induced asthma in mice. PLoS One. 2013;8(2):e56447. doi:10.1371/journal.pone.0056447

Cahyono, B., Amalina, N.D., Suzery, M. and Nur Wahyu Bima, D. 2021. Exploring the Capability of Indonesia Natural Medicine Secondary Metabolite as Potential Inhibitors of SARS-CoV-2 Proteins to Prevent Virulence of COVID-19: In silico and Bioinformatic Approach. Open Access Macedonian Journal of Medical Sciences. 9, A (May 2021), 336–342.

Kanjanasirirat, P., Suksatu, A., Manopwisedjaroen, S. et al. High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents. Sci Rep 10, 19963 (2020). https://doi.org/10.1038/s41598-020-77003-3

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